Yazar "Bilge, S. Sirri" için listeleme
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Antidepressant-like effects of echo-planar magnetic resonance imaging in mice determined using the forced swimming test
Aksoz, Elif; Aksoz, Tolga; Bilge, S. Sirri; Ilkaya, Fatih; Celik, Suleyman; Diren, H. Baris (Elsevier, 2008)Echo-planar magnetic resonance imaging (EP-MRI), which is novel variant of MRI, is thought to have antidepressant properties in humans and animal models. Using the forced swimming test (FST), we investigated which monoaminergic ... -
The antinociceptive effect of intravenous imipramine in colorectal distension-induced visceral pain in rats: the role of serotonergic and noradrenergic receptors
Ilkaya, Fatih; Bilge, S. Sirri; Bozkurt, Ayhan; Bas, Duygu B.; Erdal, Arzu; Ciftcioglu, Engin; Kesim, Yuksel (Pergamon-Elsevier Science Ltd, 2014)It has been shown that imipramine, a tricyclic antidepressant (TCA), is a potent analgesic agent. However, the effect of imipramine on visceral pain has not been extensively investigated. In the current study, our aim was ... -
The Antinociceptive Effects of Intravenous Dexmedetomidine in Colorectal Distension-Induced Visceral Pain in Rats: the Role of Opioid Receptors
Ulger, Fatma; Bozkurt, Ayhan; Bilge, S. Sirri; Ilkaya, Fatih; Dilek, Ahmet; Bostanci, M. Oemer; Guldogus, Fuat (Lippincott Williams & Wilkins, 2009)BACKGROUND: In comparison with cutaneous pain, the role of alpha(2)-adrenoceptor (alpha(2)-AR) agonists in visceral pain has not been extensively examined. We aimed to characterize the antinociceptive effect of IV ... -
The antinociceptive effects of intravenous tianeptine in colorectal distension-induced visceral pain in rats: the role of 5-HT3 receptors
Bilge, S. Sirri; Bozkurt, Ayhan; Ilkaya, Fatih; Ciftcioglu, Engin; Kesim, Yuksel; Uzbay, Tayfun I. (Elsevier, 2012)Tianeptine is an unusual tricyclic antidepressant drug. In this study, we aimed to investigate the antinociceptive effect of tianeptine on visceral pain in rats and to determine whether possible antinociceptive effect of ... -
Effect of nonsteroidal anti-inflammatory drugs on colorectal distension-induced visceral pain
Baskin, Veysel; Bilge, S. Sirri; Bozkurt, Ayhan; Akyuz, Bahar; Agri, Arzu Erdal; Guzel, Hasan; Ilkaya, Fatih (Medknow Publications & Media Pvt Ltd, 2016)Objectives: To investigate nonsteroidal anti-inflammatory drugs effectiveness in colorectal distension (CRD)-induced visceral pain model. Materials and Methods: Male Sprague-Dawley (250-300 g) rats were anesthetized with ... -
Effects of agomelatine in rotenone-induced Parkinson's disease in rats
Gunaydin, Caner; Avci, Bahattin; Bozkurt, Ayhan; Onger, Mehmet Emin; Balci, Hakan; Bilge, S. Sirri (Elsevier Ireland Ltd, 2019)The effects of melatonin and melatonin analogs in experimental Parkinson's disease (PD) models remain controversial. Agomelatine, a novel analog of melatonin, is both agonists for melatonin-1 and melatonin-2 receptors and ... -
Effects of Nonsteroidal Anti-Inflammatory Drugs at the Molecular Level
Gunaydin, Caner; Bilge, S. Sirri (Aves, 2018)Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for their anti-inflammatory, analgesic, and antipyretic effects. NSAIDs generally work by blocking the production of prostaglandins (PGs) through the inhibition ... -
Opioid Receptors Contribute to Antinociceptive Effect of Tianeptine on Colorectal Distension-Induced Visceral Pain in Rats
Bilge, S. Sirri; Ilkaya, Fatih; Darakci, Ozge; Ciftcioglu, Engin; Bozkurt, Ayhan (Karger, 2018)Tianeptine is a clinically effective atypical antidepressant with distinct neurochemical properties. In this study, we aimed to investigate the contribution of opioid receptors in the antinociceptive effect of tianeptine ... -
Proconvulsant effect of trans-cinnamaldehyde in pentylenetetrazole-induced kindling model of epilepsy: the role of TRPA1 channels
Gunaydin, Caner; Arslan, Gokhan; Bilge, S. Sirri (Elsevier Ireland Ltd, 2020)The transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily, is widely distributed in the central nervous system (CNS) and plays an important role in pain and inflammation. However, no data has been ... -
Protective effects of dietary omega-3 fatty acid supplementation on organophosphate poisoning
Avci, Bahattin; Bilge, S. Sirri; Arslan, Gokhan; Alici, Omer; Darakci, Ozge; Baratzada, Turkhan; Bozkurt, Ayhan (Sage Publications Inc, 2018)In this study, we aimed to study the possible preventive effect of docosahexaenoic acid (DHA), a dietary omega-3 fatty acid, on toxicity caused by chlorpyrifos (CPF). Six groups of Sprague Dawley rats (200-250 g) consisting ... -
Rational drug therapy education in clinical phase carried out by task-based learning
Bilge, S. Sirri; Akyuz, Bahar; Agri, Arzu Erdal; Midik, Ozlem (Medknow Publications & Media Pvt Ltd, 2017)Objectives: Irrational drug use results in drug interactions, treatment noncompliance, and drug resistance. Rational pharmacotherapy education is being implemented in many faculties of medicine. Our aim is to introduce ... -
The role of muscarinic and serotonergic-2A receptors in the antinociceptive effect of pregabalin
Hallak, Mohamad; Balci, Hakan; Gunaydin, Caner; Bilge, S. Sirri (Iranian Soc Physiology & Pharmacology, 2019)Introduction: Pregabalin (PGB) is an analog of gamma-aminobutyric acid (GABA) with antinociceptive, antihyperalgesic and antiallodynic properties which frequently used in clinical pain management. Effect of PBG in neuropathic ... -
Studies on Synthesis and Anti-inflammatory Activities of Novel 1,2,4-Triazolo[3,4-b]-1,3,4-thiadiazines
Koksal, Meric; Ozkan, Irem; Yarim, Mine; Bilge, S. Sirri; Bozkurt, Ayhan; Erol, Dilek Demir (Chiminform Data S A, 2011)In this study, synthesis of a series of 3,6-diaryl-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines by the condensation of appropriate 5-(3,4-dichlorophenyl)-2-(aroylmethyl)thio-1,3,4-oxadiazoles and hydrazine hydrate in acetic ... -
Synthesis and antidepressant-like profile of novel 1-aryl-3-[(4-benzyl)piperidine-1-yl]propane derivatives
Koksal, Meric; Bilge, S. Sirri (Wiley-V C H Verlag Gmbh, 2007)This study describes the chemical synthesis and pharmacological evaluation of some new 1-aryl-3-[(4-benzyl)piperidine-1-yl]propane derivatives as antidepressants. The structures attributed to the compounds were elucidated ... -
Synthesis, Characterization and Anti-inflammatory Activity of New 5-(3,4-Dichlorophenyl)-2-(aroylmethyl)thio-1,3,4-oxadiaxoles
Koksal, Meric; Bilge, S. Sirri; Bozkurt, Ayhan; Sahin, Z. Sibel; Isik, Samil; Erol, Dilek Demir (Ecv-Editio Cantor Verlag Medizin Naturwissenschaften, 2008)Several 5-(3,4-dichlorophenvi)-2(aroylmethyl)thio-1,3,4-oxadiazoles were synthesized and characterized by elemental analyses, IR and nuclear magnetic resonance spectra. All compounds were evaluated for anti-inflammatory ...
