Yazar "Bozkurt, Ayhan" için listeleme
-
The antinociceptive effect of intravenous imipramine in colorectal distension-induced visceral pain in rats: the role of serotonergic and noradrenergic receptors
Ilkaya, Fatih; Bilge, S. Sirri; Bozkurt, Ayhan; Bas, Duygu B.; Erdal, Arzu; Ciftcioglu, Engin; Kesim, Yuksel (Pergamon-Elsevier Science Ltd, 2014)It has been shown that imipramine, a tricyclic antidepressant (TCA), is a potent analgesic agent. However, the effect of imipramine on visceral pain has not been extensively investigated. In the current study, our aim was ... -
The Antinociceptive Effects of Intravenous Dexmedetomidine in Colorectal Distension-Induced Visceral Pain in Rats: the Role of Opioid Receptors
Ulger, Fatma; Bozkurt, Ayhan; Bilge, S. Sirri; Ilkaya, Fatih; Dilek, Ahmet; Bostanci, M. Oemer; Guldogus, Fuat (Lippincott Williams & Wilkins, 2009)BACKGROUND: In comparison with cutaneous pain, the role of alpha(2)-adrenoceptor (alpha(2)-AR) agonists in visceral pain has not been extensively examined. We aimed to characterize the antinociceptive effect of IV ... -
The antinociceptive effects of intravenous tianeptine in colorectal distension-induced visceral pain in rats: the role of 5-HT3 receptors
Bilge, S. Sirri; Bozkurt, Ayhan; Ilkaya, Fatih; Ciftcioglu, Engin; Kesim, Yuksel; Uzbay, Tayfun I. (Elsevier, 2012)Tianeptine is an unusual tricyclic antidepressant drug. In this study, we aimed to investigate the antinociceptive effect of tianeptine on visceral pain in rats and to determine whether possible antinociceptive effect of ... -
Chronic treatment with fluoxetine and sertraline prevents forced swimming test-induced hypercontractility of rat detrusor muscle
Bilge, Sirri; Bozkurt, Ayhan; Basl, Duygu B.; Aksoz, Elif; Savli, Evren; Ilkaya, Fatih; Kesim, Yuksel (Polish Acad Sciences Inst Pharmacology, 2008)Serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitors represent important targets for the development of new treatments for detrusor overactivity and urinary incontinence. The present study was undertaken to investigate ... -
Effect of nonsteroidal anti-inflammatory drugs on colorectal distension-induced visceral pain
Baskin, Veysel; Bilge, S. Sirri; Bozkurt, Ayhan; Akyuz, Bahar; Agri, Arzu Erdal; Guzel, Hasan; Ilkaya, Fatih (Medknow Publications & Media Pvt Ltd, 2016)Objectives: To investigate nonsteroidal anti-inflammatory drugs effectiveness in colorectal distension (CRD)-induced visceral pain model. Materials and Methods: Male Sprague-Dawley (250-300 g) rats were anesthetized with ... -
Effect of prenatal levetiracetam exposure on motor and cognitive functions of rat offspring
Ozyurek, Hamit; Bozkurt, Ayhan; Bilge, Sirri; Ciftcioglu, Engin; Ilkaya, Fatih; Bas, Duygu Belkis (Elsevier Science Bv, 2010)Purpose. We aimed to establish the physical, motor, and cognitive teratogenic effect of levetiracetam exposure throughout pregnancy in rats. Methods. Thirty-two Sprague Dawley pregnant female rats were divided into four ... -
The Effect of Spexin on the Contractility of Isolated Rat Small Intestine
Darakci, Ozge; Akyuz, Bahar; Bilge, Suleyman Sirri; Bozkurt, Ayhan (Wiley-Blackwell, 2015)… -
Effects of agomelatine in rotenone-induced Parkinson's disease in rats
Gunaydin, Caner; Avci, Bahattin; Bozkurt, Ayhan; Onger, Mehmet Emin; Balci, Hakan; Bilge, S. Sirri (Elsevier Ireland Ltd, 2019)The effects of melatonin and melatonin analogs in experimental Parkinson's disease (PD) models remain controversial. Agomelatine, a novel analog of melatonin, is both agonists for melatonin-1 and melatonin-2 receptors and ... -
Evaluation of Antinociceptive and Neurotoxic Effects of Intrathecal Dexmedetomidine in Rats
Isguzar, Ozgu; Baris, Sibel; Bozkurt, Ayhan; Can, Bilge; Bilge, Sirri; Ture, Hatice (Galenos Yayincilik, 2012)Objective: Dexmedetomidine has been reported to produce analgesia after intrathecal administration. In the present study the alpha 2-adrenoceptor agonist dexmedetomidine was evaluated for its potential spinal neurotoxic ... -
Evaluation of Postoperative Anti-nociceptive Efficacy of Intrathecal Dexketoprofen in Rats
Er, Birol Muhammet; Kocamanoglu, Ismail Serhat; Bozkurt, Ayhan; Bilge, Sirri; Cetinoglu, Erhan Cetin (Aves, 2016)Background: Some studies have suggested that the intrathecal use of cyclooxygenase enzyme inhibitors provides an anti-nociceptive effect. Therefore, the occurrence of side effects seen in systemic usage can be eliminated. ... -
Intracerebroventricular Application of Dexmedetomidine Produces Antinociception and Does not Cause Neurotoxicity in Rats
Koksal, Ersin; Karakaya, Deniz; Can, Bilge; Bozkurt, Ayhan; Baris, Sibel; Bilge, Suleyman Sirri; Ustun, Yasemin Burcu (Galenos Yayincilik, 2013)Background: Alpha 2 agonists contribute to pain control at the level of the medulla spinalis. Alpha 2 agonists are generally added to local anaesthetics to prolong spinal or epidural anaesthesia time. Aims: In the present ... -
Opioid Receptors Contribute to Antinociceptive Effect of Tianeptine on Colorectal Distension-Induced Visceral Pain in Rats
Bilge, S. Sirri; Ilkaya, Fatih; Darakci, Ozge; Ciftcioglu, Engin; Bozkurt, Ayhan (Karger, 2018)Tianeptine is a clinically effective atypical antidepressant with distinct neurochemical properties. In this study, we aimed to investigate the contribution of opioid receptors in the antinociceptive effect of tianeptine ... -
Protective effect of vitamin A on ARA-C induced intestinal damage in mice
Elli, Murat; Aydin, Oguz; Bilge, Sirri; Bozkurt, Ayhan; Dagdemir, Ayhan; Pinarli, Faruk Guclu; Acar, Sabri (Sage Publications Ltd, 2009)Background. Cytarabine (ARA-C) has been used for many years in the treatment of patients with leukemia and lymphoma. Gastrointestinal ulceration and mucositis are two of the well-known side effects of ARA-C. We set out to ... -
Protective effects of dietary omega-3 fatty acid supplementation on organophosphate poisoning
Avci, Bahattin; Bilge, S. Sirri; Arslan, Gokhan; Alici, Omer; Darakci, Ozge; Baratzada, Turkhan; Bozkurt, Ayhan (Sage Publications Inc, 2018)In this study, we aimed to study the possible preventive effect of docosahexaenoic acid (DHA), a dietary omega-3 fatty acid, on toxicity caused by chlorpyrifos (CPF). Six groups of Sprague Dawley rats (200-250 g) consisting ... -
The role of heart-type fatty acid-binding protein in the evaluation of carbon monoxide poisoning in rats
Yardan, Turker; Meric, Murat; Bozkurt, Ayhan; Bilge, Sirri; Bas, Duygu Belkis; Bedir, Abdulkerim; Baydin, Ahmet (Sage Publications Ltd, 2011)Acute carbon monoxide (CO) poisoning can cause early and persistent damages in tissues sensitive to hypoxia. This study investigated serum heart-type fatty acid-binding protein (H-FABP) levels as a biomarker of acute CO ...
