Yazar "Ekinci, Deniz" için listeleme
-
Acute and long-term genotoxicity of deltamethrin to insulin-like growth factors and growth hormone in rainbow trout
Aksakal, Ercument; Ceyhun, Saltuk Bugrahan; Erdogan, Orhan; Ekinci, Deniz (Elsevier Science Inc, 2010)We report here the acute and long-term influences of deltamethrin on the expression of IGF-I, IGF-II and GH-I in rainbow trout muscles. We treated rainbow trouts with different concentrations of deltamethrin (0.25 mu g/L, ... -
alpha-Carbonic anhydrases are sulfatases with cyclic diol monosulfate esters
Cavdar, Huseyin; Ekinci, Deniz; Talaz, Oktay; Saracoglu, Nurullah; Senturk, Murat; Supuran, Claudiu T. (Taylor & Francis Ltd, 2012)Carbonic anhydrases (CA) catalyze activated ester hydrolysis in addition to the hydration of CO 2 to bicarbonate. They also show phosphatase activity with 4-nitrophenyl phosphate as substrate but not sulfatase with the ... -
An Alternative Purification Method for Human Serum Paraoxonase 1 and its Interactions with Sulfonamides
Ekinci, Deniz; Senturk, Murat; Beydemir, Sukru; Kufrevioglu, Omar Irfan; Supuran, Claudiu T. (Wiley-Blackwell, 2010)Paraoxonase 1 (PON1), a high-density lipoprotein (HDL)-associated esterase, is known to mediate antioxidant and antiatherogenic properties. Purification of PON1 has been challenging for a long time. Here, we report a novel ... -
Analysis of saponins and phenolic compounds as inhibitors of alpha-carbonic anhydrase isoenzymes
Koz, Omer; Ekinci, Deniz; Perrone, Angela; Piacente, Sonia; Alankus-Caliskan, Ozgen; Bedir, Erdal; Supuran, Claudiu T. (Taylor & Francis Ltd, 2013)A series of phenolic and saponin type natural products such as quercetin, rutin, catechin, epicatechin, silymarin, trojanoside H, astragaloside IV, astragaloside VIII and astrasieversianin X, were investigated for their ... -
Assesment of metal inhibition of antioxidant enzyme glutathione reductase from rainbow trout liver
Ekinci, Deniz; Senturk, Murat (Taylor & Francis Ltd, 2013)Effects of Co+2, Zn+2, Ca+2, Fe+2, Mn+2, Cr+3, Sn+2 and Mg+2 exposure of rainbow trout liver on the enzymatic activity of glutathione reductase (GR) were investigated. GR was purified from rainbow trout liver 1419-fold ... -
Biological Evaluation of Some Uracil Derivatives as Potent Glutathione Reductase Inhibitors
Guney, Murat; Ekinci, Deniz; Cavdar, Huseyin; Senturk, Murat; Zilbeyaz, Kani (Amer Inst Physics, 2016)Discovery of glutathione reductase (GR) inhibitors has become very popular recently due to antimalarial and anticancer activities. In this study, GR inhibitory capacities of some uracil derivatives (UDCs) (1-4) were reported. ... -
Carbonic anhydrase from Apis mellifera: purification and inhibition by pesticides
Soydan, Ercan; Guler, Ahmet; Biyik, Selim; Senturk, Murat; Supuran, Claudiu T.; Ekinci, Deniz (Taylor & Francis Ltd, 2017)Carbonic anhydrase (CA) enzymes have been shown to play an important role in ion transport and in pH regulation in several organisms. Despite this information and the wealth of knowledge regarding the significance of CA ... -
Carbonic anhydrase inhibitors: Design, synthesis, kinetic, docking and molecular dynamics analysis of novel glycine and phenylalanine sulfonamide derivatives
Fidan, Ismail; Salmas, Ramin Ekhteiari; Arslan, Mehmet; Senturk, Murat; Durdagi, Serdar; Ekinci, Deniz; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2015)The inhibition of two human cytosolic carbonic anhydrase isozymes I and II, with some novel glycine and phenylalanine sulfonamide derivatives were investigated. Newly synthesized compounds G1-4 and P1-4 showed effective ... -
Carbonic anhydrase inhibitors: in vitro inhibition of alpha isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids
Ekinci, Derya; Karagoz, Lutfi; Ekinci, Deniz; Senturk, Murat; Supuran, Claudiu T. (Taylor & Francis Ltd, 2013)A series of flavonoids, such as quercetin, catechin, apigenin, luteolin, morin, were investigated for their inhibitory effects against the metalloenzyme carbonic anhydrase (CA). The compounds were tested against four ... -
Carbonic anhydrase inhibitors: inhibition of human and bovine isoenzymes by benzenesulphonamides, cyclitols and phenolic compounds
Ekinci, Deniz; Kurbanoglu, Namudar I.; Salamci, Emine; Senturk, Murat; Supuran, Claudiu T. (Taylor & Francis Ltd, 2012)Carbonic anhydrase inhibitors (CAIs) are a class of pharmaceuticals used as anti-glaucoma agents, diuretics and anti-epileptics. We report here the inhibitory capacities of benzenesulphonamides, cyclitols and phenolic ... -
Carbonic anhydrase inhibitory properties of some uracil derivatives
Turkoglu, Emir Alper; Senturk, Murat; Supuran, Claudiu T.; Ekinci, Deniz (Taylor & Francis Ltd, 2017)Inhibitors of carbonic anhydrase (CA) have been carried out in many therapeutic applications, especially antiglaucoma activity. In this study, we investigated some uracil derivatives (4-12) to inhibit human CA I (hCA I) ... -
Characterization and anions inhibition studies of an alpha-carbonic anhydrase from the teleost fish Dicentrarchus labrax
Ekinci, Deniz; Ceyhun, Saltuk Bugrahan; Senturk, Murat; Erdem, Deryanur; Kufrevioglu, Omer Irfan; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2011)Carbonic anhydrase (CA; EC 4.2.1.1) was purified from the gill of the teleost fish Dicentrarchus labrax (European seabass). The purification procedure consisted of a single step affinity chromatography on Sepharose ... -
Characterization of carbonic anhydrase from Turkish native "Gerze" chicken and influences of metal ions on enzyme activity
Mercan, Levent; Ekinci, Deniz; Supuran, Claudiu T. (Taylor & Francis Ltd, 2014)Carbonic anhydrase was purified and characterized from erythrocytes of the Turkish native chicken, Gerze, for the first time. The enzyme was purified 57.65-fold with a yield of 52%, and a specific activity of 954.08 U/mg ... -
Chromone containing sulfonamides as potent carbonic anhydrase inhibitors
Ekinci, Deniz; al-Rashida, Mariya; Abbas, Ghulam; Senturk, Murat; Supuran, Claudiu T. (Taylor & Francis Ltd, 2012)A series of sulfonamide derivatives incorporating substituted 3-formylchromone moieties were investigated for the inhibition of three human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms, hCA I, II, and VI. All these ... -
Comparing Biochemical Properties of Pure and Adulterated Honeys Produced By Feeding Honeybees (Apis mellifera L.) Colonies with Different Levels of Industrial Commercial Sugars([1])
Guler, Ahmet; Garipoglu, Ali V.; Onder, Hasan; Biyik, Selim; Kocaokutgen, Hasan; Ekinci, Deniz (Kafkas Univ, Veteriner Fakultesi Dergisi, 2017)In the present study, 100 pure and adulterated honey samples produced by feeding colonies with different levels (5, 20 and 100 L/colony) of various commercial industrial sugar syrups such as High Fructose Corn Syrup 85 ... -
Comparison of blood carbonic anhydrase activity of athletes performing interval and continuous running exercise at high altitude
Tas, Murat; Senturk, Esra; Ekinci, Deniz; Demirdag, Ramazan; Comakli, Veysal; Bayram, Metin; Supuran, Claudiu T. (Taylor & Francis Ltd, 2019)The effects of high-intensity interval and continuous exercise on erythrocytes carbonic anhydrase (CA, EC 4.2.1.1) activity levels were scarcely investigated up until now. Here we present a study focused on the CA activity ... -
Deltamethrin attenuates antioxidant defense system and induces the expression of heat shock protein 70 in rainbow trout
Ceyhun, Saltuk Bugrahan; Senturk, Murat; Ekinci, Deniz; Erdogan, Orhan; Ciltas, Abdulkadir; Kocaman, Esat Mahmut (Elsevier Science Inc, 2010)The current research aims to determine alterations in gene expression and enzymatic activity of fish antioxidant metabolism in response to pesticide administration. To this end, three different deltamethrin concentrations ... -
Design, synthesis and biological evaluation of novel nitroaromatic compounds as potent glutathione reductase inhibitors
Cakmak, Resit; Durdagi, Serdar; Ekinci, Deniz; Senturk, Murat; Topal, Giray (Pergamon-Elsevier Science Ltd, 2011)Discovery of GR inhibitors has become very popular recently due to antimalarial and anticancer activities. In this study, the synthesis and GR inhibitory capacities of novel nitroaromatic compounds (NCs) (1-3) were reported. ... -
Design, synthesis and molecular modelling studies of some pyrazole derivatives as carbonic anhydrase inhibitors
Dizdaroglu, Yazgi; Albay, Canan; Arslan, Tayfun; Ece, Abdulilah; Turkoglu, Emir A.; Efe, Asiye; Ekinci, Deniz (Taylor & Francis Ltd, 2020)In this study, newly synthesised compounds 6, 8, 10 and other compounds (1-5, 7 and 9) and their inhibitory properties against the human isoforms hCA I and hCA II were reported for the first time. Compounds 1-10 showed ...
