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The antinociceptive effect of intravenous imipramine in colorectal distension-induced visceral pain in rats: the role of serotonergic and noradrenergic receptors
Ilkaya, Fatih; Bilge, S. Sirri; Bozkurt, Ayhan; Bas, Duygu B.; Erdal, Arzu; Ciftcioglu, Engin; Kesim, Yuksel (Pergamon-Elsevier Science Ltd, 2014)It has been shown that imipramine, a tricyclic antidepressant (TCA), is a potent analgesic agent. However, the effect of imipramine on visceral pain has not been extensively investigated. In the current study, our aim was ... -
The antinociceptive effects of intravenous tianeptine in colorectal distension-induced visceral pain in rats: the role of 5-HT3 receptors
Bilge, S. Sirri; Bozkurt, Ayhan; Ilkaya, Fatih; Ciftcioglu, Engin; Kesim, Yuksel; Uzbay, Tayfun I. (Elsevier, 2012)Tianeptine is an unusual tricyclic antidepressant drug. In this study, we aimed to investigate the antinociceptive effect of tianeptine on visceral pain in rats and to determine whether possible antinociceptive effect of ... -
Chronic treatment with fluoxetine and sertraline prevents forced swimming test-induced hypercontractility of rat detrusor muscle
Bilge, Sirri; Bozkurt, Ayhan; Basl, Duygu B.; Aksoz, Elif; Savli, Evren; Ilkaya, Fatih; Kesim, Yuksel (Polish Acad Sciences Inst Pharmacology, 2008)Serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitors represent important targets for the development of new treatments for detrusor overactivity and urinary incontinence. The present study was undertaken to investigate ... -
Effect of Prenatal Exposure to Diclofenac Sodium on the Development of Arteries in the Female Rat A Stereological and Histopathological Evaluation
Colakoglu, Serdar; Altunkaynak, Muhammed Eyup; Zengin, Halit; Elibol, Ebru; Altunkaynak, Berrin Zuhal; Kesim, Yuksel; Kaplan, Süleyman (Sci Printers & Publ Inc, 2016)OBJECTIVE: To investigate the effect of diclofenac sodium (DS) exposure on the prenatal development of female rat arteries. STUDY DESIGN: Pregnant rats were separated into control, saline-injected, and drug-treated (DS) ...