Yazar "Supuran, Claudiu T." için listeleme
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alpha-Carbonic anhydrases are sulfatases with cyclic diol monosulfate esters
Cavdar, Huseyin; Ekinci, Deniz; Talaz, Oktay; Saracoglu, Nurullah; Senturk, Murat; Supuran, Claudiu T. (Taylor & Francis Ltd, 2012)Carbonic anhydrases (CA) catalyze activated ester hydrolysis in addition to the hydration of CO 2 to bicarbonate. They also show phosphatase activity with 4-nitrophenyl phosphate as substrate but not sulfatase with the ... -
An Alternative Purification Method for Human Serum Paraoxonase 1 and its Interactions with Sulfonamides
Ekinci, Deniz; Senturk, Murat; Beydemir, Sukru; Kufrevioglu, Omar Irfan; Supuran, Claudiu T. (Wiley-Blackwell, 2010)Paraoxonase 1 (PON1), a high-density lipoprotein (HDL)-associated esterase, is known to mediate antioxidant and antiatherogenic properties. Purification of PON1 has been challenging for a long time. Here, we report a novel ... -
Analysis of saponins and phenolic compounds as inhibitors of alpha-carbonic anhydrase isoenzymes
Koz, Omer; Ekinci, Deniz; Perrone, Angela; Piacente, Sonia; Alankus-Caliskan, Ozgen; Bedir, Erdal; Supuran, Claudiu T. (Taylor & Francis Ltd, 2013)A series of phenolic and saponin type natural products such as quercetin, rutin, catechin, epicatechin, silymarin, trojanoside H, astragaloside IV, astragaloside VIII and astrasieversianin X, were investigated for their ... -
Carbonic anhydrase from Apis mellifera: purification and inhibition by pesticides
Soydan, Ercan; Guler, Ahmet; Biyik, Selim; Senturk, Murat; Supuran, Claudiu T.; Ekinci, Deniz (Taylor & Francis Ltd, 2017)Carbonic anhydrase (CA) enzymes have been shown to play an important role in ion transport and in pH regulation in several organisms. Despite this information and the wealth of knowledge regarding the significance of CA ... -
Carbonic anhydrase inhibitors: Design, synthesis, kinetic, docking and molecular dynamics analysis of novel glycine and phenylalanine sulfonamide derivatives
Fidan, Ismail; Salmas, Ramin Ekhteiari; Arslan, Mehmet; Senturk, Murat; Durdagi, Serdar; Ekinci, Deniz; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2015)The inhibition of two human cytosolic carbonic anhydrase isozymes I and II, with some novel glycine and phenylalanine sulfonamide derivatives were investigated. Newly synthesized compounds G1-4 and P1-4 showed effective ... -
Carbonic anhydrase inhibitors: in vitro inhibition of alpha isoforms (hCA I, hCA II, bCA III, hCA IV) by flavonoids
Ekinci, Derya; Karagoz, Lutfi; Ekinci, Deniz; Senturk, Murat; Supuran, Claudiu T. (Taylor & Francis Ltd, 2013)A series of flavonoids, such as quercetin, catechin, apigenin, luteolin, morin, were investigated for their inhibitory effects against the metalloenzyme carbonic anhydrase (CA). The compounds were tested against four ... -
Carbonic anhydrase inhibitors: inhibition of human and bovine isoenzymes by benzenesulphonamides, cyclitols and phenolic compounds
Ekinci, Deniz; Kurbanoglu, Namudar I.; Salamci, Emine; Senturk, Murat; Supuran, Claudiu T. (Taylor & Francis Ltd, 2012)Carbonic anhydrase inhibitors (CAIs) are a class of pharmaceuticals used as anti-glaucoma agents, diuretics and anti-epileptics. We report here the inhibitory capacities of benzenesulphonamides, cyclitols and phenolic ... -
Carbonic anhydrase inhibitory properties of some uracil derivatives
Turkoglu, Emir Alper; Senturk, Murat; Supuran, Claudiu T.; Ekinci, Deniz (Taylor & Francis Ltd, 2017)Inhibitors of carbonic anhydrase (CA) have been carried out in many therapeutic applications, especially antiglaucoma activity. In this study, we investigated some uracil derivatives (4-12) to inhibit human CA I (hCA I) ... -
Characterization and anions inhibition studies of an alpha-carbonic anhydrase from the teleost fish Dicentrarchus labrax
Ekinci, Deniz; Ceyhun, Saltuk Bugrahan; Senturk, Murat; Erdem, Deryanur; Kufrevioglu, Omer Irfan; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2011)Carbonic anhydrase (CA; EC 4.2.1.1) was purified from the gill of the teleost fish Dicentrarchus labrax (European seabass). The purification procedure consisted of a single step affinity chromatography on Sepharose ... -
Characterization of carbonic anhydrase from Turkish native "Gerze" chicken and influences of metal ions on enzyme activity
Mercan, Levent; Ekinci, Deniz; Supuran, Claudiu T. (Taylor & Francis Ltd, 2014)Carbonic anhydrase was purified and characterized from erythrocytes of the Turkish native chicken, Gerze, for the first time. The enzyme was purified 57.65-fold with a yield of 52%, and a specific activity of 954.08 U/mg ... -
Chromone containing sulfonamides as potent carbonic anhydrase inhibitors
Ekinci, Deniz; al-Rashida, Mariya; Abbas, Ghulam; Senturk, Murat; Supuran, Claudiu T. (Taylor & Francis Ltd, 2012)A series of sulfonamide derivatives incorporating substituted 3-formylchromone moieties were investigated for the inhibition of three human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms, hCA I, II, and VI. All these ... -
Comparison of blood carbonic anhydrase activity of athletes performing interval and continuous running exercise at high altitude
Tas, Murat; Senturk, Esra; Ekinci, Deniz; Demirdag, Ramazan; Comakli, Veysal; Bayram, Metin; Supuran, Claudiu T. (Taylor & Francis Ltd, 2019)The effects of high-intensity interval and continuous exercise on erythrocytes carbonic anhydrase (CA, EC 4.2.1.1) activity levels were scarcely investigated up until now. Here we present a study focused on the CA activity ... -
Determination of the inhibitory effects of N-methylpyrrole derivatives on glutathione reductase enzyme
Kocaoglu, Esma; Talaz, Oktay; Cavdar, Huseyin; Senturk, Murat; Supuran, Claudiu T.; Ekinci, Deniz (Taylor & Francis Ltd, 2019)Glutathione reductase (GR) is a crucial antioxidant enzyme which is responsible for the maintenance of antioxidant GSH molecule. Antimalarial effects of some chemical molecules are attributed to their inhibition of GR, ... -
Effects of dopaminergic compounds on carbonic anhydrase isozymes I, II, and VI
Senturk, Murat; Ekinci, Deniz; Goksu, Suleyman; Supuran, Claudiu T. (Taylor & Francis Ltd, 2012)Studies on carbonic anhydrase (CA, EC 4.2.1.1) inhibitors have increased due to several therapeutic applications while there are few investigations on activators. Here we investigated CA inhibitory and activatory capacities ... -
Inhibition of acetylcholinesterase and butyrylcholinesterase with uracil derivatives: kinetic and computational studies
Cavdar, Huseyin; Senturk, Murat; Guney, Murat; Durdagi, Serdar; Kayik, Gulru; Supuran, Claudiu T.; Ekinci, Deniz (Taylor & Francis Ltd, 2019)Acetylcholinesterase (AChE) and Butyrylcholinesterase (BuChE) inhibitors are interesting compounds for different therapeutic applications, among which Alzheimer's disease. Here, we investigated the inhibition of these ... -
Interaction of carbonic anhydrase isozymes I, II, and IX with some pyridine and phenol hydrazinecarbothioamide derivatives
Isik, Semra; Vullo, Daniela; Durdagi, Serdar; Ekinci, Deniz; Senturk, Murat; Cetin, Ahmet; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2015)A series of hydrazinecarbothioamide derivatives incorporating ethyl, phenyl, tolyl, benzyl, and allyl moieties were prepared and tested as possible inhibitors of three members of the pH regulatory enzyme family, carbonic ... -
Investigation of arenesulfonyl-2-imidazolidinones as potent carbonic anhydrase inhibitors
Abdel-Aziz, Alaa A-M.; El-Azab, Adel S.; Ekinci, Deniz; Senturk, Murat; Supuran, Claudiu T. (Taylor & Francis Ltd, 2015)A series of arenesulfonyl-2-imidazolidinones incorporating methyl, isopropyl, methoxy, halogen and phenyl moieties were prepared and tested as possible inhibitors of two members of the pH regulatory enzyme family, carbonic ... -
Kinetic and docking studies of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with some hydroxylic compounds
Durdagi, Serdar; Korkmaz, Neslihan; Isik, Semra; Vullo, Daniela; Astley, Demet; Ekinci, Deniz; Supuran, Claudiu T. (Taylor & Francis Ltd, 2016)A series of hydroxylic compounds (1-10, NK-154 and NK-168) have been assayed for the inhibition of three physiologically relevant carbonic anhydrase isozymes, the cytosolic isozymes I, II and tumor-associated isozyme IX. ... -
Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site
Durdagi, Serdar; Senturk, Murat; Ekinci, Deniz; Balaydin, Halis Turker; Goksu, Suleyman; Kufrevioglu, O. Irfan; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2011)Carbonic anhydrases (CAs, EC 4.2.1.1) are inhibited by sulfonamides, inorganic anions, phenols, coumarins (acting as prodrugs) and polyamines. A novel class of CA inhibitors (CAIs), interacting with the CA isozymes I, II ... -
Kinetic and in silico analysis of thiazolidin-based inhibitors of alpha-carbonic anhydrase isoenzymes
Ekinci, Deniz; Fidan, Ismail; Durdagi, Serdar; Kaban, Seniz; Supuran, Claudiu T. (Taylor & Francis Ltd, 2013)Carbonic anhydrases (CAs, EC 4.2.1.1) are inhibited by sulfonamides, inorganic anions, phenols, salicylic acid derivatives (acting as drug or prodrugs). A novel class of CA inhibitors (CAIs), interacting with the CA isozymes ...
