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Deep Brain Stimulation of the Rat Subthalamic Nucleus Induced Inhibition of Median Raphe Serotonergic and Dopaminergic Neurotransmission
Kocabicak, Ersoy; Jahanshahi, Ali; Schonfeld, Lisa; Hescham, Sarah-Anna; Temel, Yasin; Tan, Sonny (Turkish Neurosurgical Soc, 2015)AIM: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) relieves motor dysfunction in advanced Parkinson's disease (PD). However, STN DBS treated patients can experience unpleasant and debilitating psychiatric ... -
Hyperdopaminergic Status in Experimental Huntington Disease
Jahanshahi, Ali; Vlamings, Rinske; Kaya, Ahmet Hilmi; Lim, Lee Wei; Janssen, Marcus L. F.; Tan, Sonny; Temel, Yasin (Oxford Univ Press Inc, 2010)Huntington disease has been linked to increased dopaminergic neurotransmission in the striatum, and clinical studies have demonstrated that the associated chorea can be treated with dopamine antagonist or dopamine-depleting ... -
Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats
Kaya, Ahmet H.; Vlamings, Rinske; Tan, Sonny; Lim, Lee Wei; Magill, Peter J.; Steinbusch, Harry W. M.; Temel, Yasin (Elsevier Science Bv, 2008)Serotonin (5-HT) containing neurons in the dorsal raphe nucleus (DRN) may play important roles in Parkinson's disease (PD). This study investigated neural and metabolic activity of the DRN in animal PD models based on ...