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Microtubular Dysfunction and Male Infertility

dc.contributor.authorGunes, Sezgin
dc.contributor.authorSengupta, Pallav
dc.contributor.authorHenkel, Ralf
dc.contributor.authorAlguraigari, Aabed
dc.contributor.authorSinigaglia, Mariana Marques
dc.contributor.authorKayal, Malik
dc.contributor.authorAgarwal, Ashok
dc.date.accessioned2020-06-21T12:19:12Z
dc.date.available2020-06-21T12:19:12Z
dc.date.issued2020
dc.identifier.issn2287-4208
dc.identifier.issn2287-4690
dc.identifier.urihttps://doi.org/10.5534/wjmh.180066
dc.identifier.urihttps://hdl.handle.net/20.500.12712/10363
dc.descriptionSengupta, Pallav/0000-0002-1928-5048; Gunes, Sezgin/0000-0002-3103-6482; Marques Sinigaglia, Mariana/0000-0001-5547-8384; Henkel, Ralf/0000-0003-1128-2982en_US
dc.descriptionWOS: 000503243400002en_US
dc.descriptionPubMed: 30350487en_US
dc.description.abstractMicrotubules are the prime component of the cytoskeleton along with microfilaments. Being vital for organelle transport and cellular divisions during spermatogenesis and sperm motility process, microtubules ascertain functional capacity of sperm. Also, microtubule based structures such as axoneme and manchette are crucial for sperm head and tail formation. This review (a) presents a concise, yet detailed structural overview of the microtubules, (b) analyses the role of microtubule structures in various male reproductive functions, and (c) presents the association of microtubular dysfunctions with male infertility. Considering the immense importance of microtubule structures in the formation and maintenance of physiological functions of sperm cells, this review serves as a scientific trigger in stimulating further male infertility research in this direction.en_US
dc.description.sponsorshipAmerican Center for Reproductive Medicine, Cleveland, USAen_US
dc.description.sponsorshipThe authors acknowledge the efforts of Amanda Mendelsohn, Terri O'Brian and Anthony Christovich (Center for Medical Art & Photography, Cleveland Clinic) for drawing the illustrations. Research in this study was supported by funds from American Center for Reproductive Medicine, Cleveland, USA.en_US
dc.language.isoengen_US
dc.publisherPusan Natl Univ Medical Sch, Dept Urologyen_US
dc.relation.isversionof10.5534/wjmh.180066en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAxonemeen_US
dc.subjectInfertilityen_US
dc.subjectmaleen_US
dc.subjectKartagener syndromeen_US
dc.subjectMicrotubule-associated proteinsen_US
dc.titleMicrotubular Dysfunction and Male Infertilityen_US
dc.typereviewen_US
dc.contributor.departmentOMÜen_US
dc.identifier.volume38en_US
dc.identifier.issue1en_US
dc.identifier.startpage9en_US
dc.identifier.endpage23en_US
dc.relation.journalWorld Journal of Mens Healthen_US
dc.relation.publicationcategoryDiğeren_US


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