Efficacy of perfusion CT in differentiating of pancreatic ductal adenocarcinoma from mass-forming chronic pancreatitis and characterization of isoattenuating pancreatic lesions

Abstract

PurposeMultidetector computed tomography (MDCT) is routinely used in the diagnosis of pancreatic ductal adenocarcinoma (PDAC), but it may be inadequate in some cases, especially mass-forming chronic pancreatitis (MFCP) and isoattenuating pancreatic lesions. Perfusion CT (pCT) may help resolve this problem. The aim of this study was to evaluate whether pCT could help differentiating PDAC from MFCP and in characterization of isoattenuating pancreatic lesions.Materials and methodsThis prospective study included 89 cases of pancreatic lesions detected by MDCT and further analyzed with pCT. Sixty-one cases with final pathological diagnosis PDAC and 12 cases with MFCP were included from the study. Blood volume (BV), blood flow (BF), mean transit time (MTT), and permeability surface area product (PS) maps were obtained. Perfusion values obtained from the lesions and normal parenchyma were compared.ResultsCompared with normal parenchyma, BV, BF, PS were lower and MTT was longer in PDAC and MFCP (p<0.05). Compared with MFCP, BV, BF, PS were lower and MTT was longer in PDAC (p<0.001). Compared with normal parenchyma, BV, BF, PS were lower and MTT was longer in isoattenuating lesions, (p<0.001). Cutoff values of 7.60mL/100mL, 64.43mL/100mL/min, 28.08mL/100mL/min for BV, BF, PS, respectively, provided 100% sensitivity and specificity and 7.47s for MTT provided 98.3% sensitivity, 80% specificity for distinguishing PDAC from MFCP.ConclusionpCT is a useful technology that can be helpful in overcoming the limitations of routine MDCT in diagnosing PDAC and characterization of isoattenuating lesions.