A new antibacterial silver(I) complex incorporating 2,5-dimethylpyrazine and the anti-inflammatory diclofenac

Abstract

Ag-I-containing coordination complexes have attracted attention because of their photoluminescence properties and antimicrobial activities and, in principle, these properties depend on the nature of the structural topologies. A novel two-dimensional silver(I) complex with the anti-inflammatory diclofenac molecule, namely bis{mu-2-[2-(2,6-dichloroanilino)phenyl]acetato-kappa O-3,O':O]bis(mu-2,5-dimethylpyrazine-kappa N-2:N')silver(I), [Ag-2(C14H10Cl2NO2)(2)(C6H8N2)](n), (I), has been synthesized and characterized by single-crystal X-ray diffraction, revealing that the Ag-I ions are chelated by the carboxylate groups of the anionic 2-[2-(2,6-dichloroanilino)phenyl]acetate (dicl) ligand in a mu(3)-eta(1):eta(2) coordination mode. Each did ligand links three Ag-I atoms to generate a one-dimensional infinite chain. Adjacent chains are connected through 2,5-dimethylpyrazine (dmpyz) ligands to form a two-dimensional layer structure parallel to the crystallographic be plane. The layers are further connected by C-H center dot center dot center dot pi interactions to generate a three-dimensional supramolecular structure. Additionally, the most striking feature is that the structure contains an intramolecular C-H center dot center dot center dot Ag anagostic interaction. Furthermore, the title complex has been tested for its in vitro antibacterial activity and is determined to be highly effective on the studied microorganisms.