| dc.contributor.author | Guney, Murat | |
| dc.contributor.author | Ekinci, Deniz | |
| dc.contributor.author | Cavdar, Huseyin | |
| dc.contributor.author | Senturk, Murat | |
| dc.contributor.author | Zilbeyaz, Kani | |
| dc.date.accessioned | 2020-06-21T13:40:10Z | |
| dc.date.available | 2020-06-21T13:40:10Z | |
| dc.date.issued | 2016 | |
| dc.identifier.isbn | 978-0-7354-1373-3 | |
| dc.identifier.issn | 0094-243X | |
| dc.identifier.uri | https://doi.org/10.1063/1.4945930 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12712/13769 | |
| dc.description | International Conference on Advances in Natural and Applied Sciences (ICANAS) -- APR 21-23, 2016 -- Antalya, TURKEY | en_US |
| dc.description | WOS: 000376001000104 | en_US |
| dc.description.abstract | Discovery of glutathione reductase (GR) inhibitors has become very popular recently due to antimalarial and anticancer activities. In this study, GR inhibitory capacities of some uracil derivatives (UDCs) (1-4) were reported. Some commercially available molecules (5-6) were also tested for comparison reasons. The novel UDCs were obtained in high yields using simple chemical procedures and exhibited much potent inhibitory activities against GR at low nanomolar concentrations with IC50 values ranging from 2.68 to 166.6 nM as compared with well-known agents. | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | Amer Inst Physics | en_US |
| dc.relation.ispartofseries | AIP Conference Proceedings | |
| dc.relation.isversionof | 10.1063/1.4945930 | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.title | Biological Evaluation of Some Uracil Derivatives as Potent Glutathione Reductase Inhibitors | en_US |
| dc.type | conferenceObject | en_US |
| dc.contributor.department | OMÜ | en_US |
| dc.identifier.volume | 1726 | en_US |
| dc.relation.journal | International Conference on Advances in Natural and Applied Sciences: Icanas 2016 | en_US |
| dc.relation.publicationcategory | Konferans Öğesi - Uluslararası - Kurum Öğretim Elemanı | en_US |
