t(6;9)(p23;q34) Presenting Acute Myeloid Leukemia in a Child With an Unsuspected 45,X/46,X,derY [?t(Yp;Yq)] Chromosomal Constitution: Yet Another Y Chromosome Overdosage and Malignancy Association

Abstract

Development of leukemia in patients with sexual chromosome abnormalities is relatively rare and mostly involves cases of monosomy X, Turner syndrome. Here, we report on a child having a 45,X/46,X,derY [?t(Yp;Yq)] chromosomal constitution (variant Turner syndrome) presenting with concordant acute myeloid leukemia and a rarely seen clonal neoplasic cell lineage-related karyotype, t(6;9)(p23;q34).