Determination of ticlopidine in pharmaceutical products

Abstract

The voltammetric behaviour of ticlopidine-HCl was studied using square-wave, sampled direct current and cyclic voltammetry. The drug showed a cathodic peak at -0.01V versus Ag/AgCl with hanging mercury drop electrode. The current was investigated using cyclic voltammetry and characterized as diffusion controlled. The calibration plot was linear over the concentration range of 1.96 x 10(-6) -1.13 x 10(-4) M in 0.5 M phosphate buffer of pH 5.0. Limit of detection and limit of quantification were achieved as 5.17 x 10(-7), 1.72 x 10(-6) M, respectively. Precision and accuracy of the developed method was checked by recovery studies. The proposed procedure was successfully applied for assay of ticlopidine in its pharmaceutical formulation as tablet without the necessity for sample pretreatment prior to assay of the drug.