Germ cell tumor showing partial trisomy 1 in a gonadectomized intersex child with monosomy X and double Y mosaicism
Tarih
2006Yazar
Ogur, GonulPinarli, Faruk Guclu
Dagdemir, Ayhan
Artan, Sevilhan
Ariturk, Ender
Elli, Murat
Okten, Gulsen
Üst veri
Tüm öğe kaydını gösterÖzet
High incidence of germ cell tumors arising from dysgenetic gonads in patients with sexual chromosome abnormalities has been described, especially in patients with a Y chromosome bearing cell line. Here we report a 14-year-old patient with ambiguous genitalia. Constitutional karyotype showed 45,X/46,X,derY [?t(Yp;Yq)] mosaicism. The patient developed an abdominally located mixed malignant germ cell tumor 5 years after the removal of the dysgenetic gonads. Tumor karyotype showed partial trisomy 1q, a derivative 8q, and a hyperdiploidy with + X, + 7, + 12, + 15, + 19, + 21, and an unidentified marker.
Kaynak
Journal of Pediatric Hematology OncologyCilt
28Sayı
11Bağlantı
https://doi.org/10.1097/01.mph.0000243651.33561.d4https://hdl.handle.net/20.500.12712/20363