Effects of lidocaine and prednisolone on endoscopic rigid laryngoscopy

Abstract

Objective/Hypothesis. The aim of this study is to compare the effects of lidocaine and methylprednisolone on postoperative respiratory complications caused by short-term laryngeal surgery by way of rigid laryngoscope under general anesthesia. The effects of these drugs on recovery from anesthesia are also compared. Study Design. One hundred American Society of Anesthesiologists physical status I to II patients over 20 years of age admitted for laryngeal mass, nodule, or polyp were included in this prospective, placebo-controlled, randomized, and double-blinded study. Methods: Patients were randomly allocated to four groups; methylprednisolone 3 mg.kg(-1) (group 1), 0.9% saline physiologic 5 mL (group 2), lidocaine 1.5 mg.kg(-1) (group 3) intravenously, seven puffs of lidocaine aerosol 10% to oropharyngolaryngeal structures topically (group 4) sprayed. Anesthesia recovery time was calculated. Respiratory system was evaluated using a scoring table during early postoperative period. Results: Ninety-two cases were suitable for analysis. Recovery time was longer in group 1 (9.83 +/- 3.79 minutes) than in groups 3 and 4 (7.22 +/- 2.38, 7.50 +/- 2.30 minutes, respectively) (P<.05). Postoperative respiratory complications were lower in groups 3 and 4 than group 2 (P<.05). Conclusions: Lidocaine intravenous or topical administration was effective in reducing postoperative respiratory complications after short-term laryngeal surgery by way of rigid laryngoscope. Methylprednisolone prolonged recovery time from anesthesia.