Primary hyperparathyroidism: A single-center experience

Abstract

ABS TRACT Objective: Primary hyperparathyroidism (PHPT) is characterized by hypercalcemia and elevated parathyroid hormone (PTH) levels. In this study, we aimed to report our clinical experience by presenting the demographic, laboratory, and clinical features of our PHPT patients. Material and Methods: A total of 217 patients who underwent parathyroidectomy from 2010 to 2018 at Ondokuz Mayıs University General Surgery Clinic were retrospectively reviewed, and PHPT patients who were diagnosed with parathyroid adenoma were further evaluated. Results: In total, 136 patients (85.3% females) with a mean age of 52.6±12.66 years were included. The prevalence of osteoporosis, nephrolithiasis, hypercalciuria, and vitamin D deficiency were 45.3%, 21.7%, 59.0%, and 63.8%, respectively. Postoperative hypocalcemia (21.3%) was only related with low preoperative calcium levels (p=0.002). Preoperative calcium was positively correlated with age (p=0.029), parathyroid adenoma weight (PAW) (p=0.009), and preoperative PTH (p<0.001) and negatively correlated with 25(OH)D3 (p=0.048). Preoperative PTH was positively correlated with PAW (p=0.002) and negatively correlated with 25(OH)D3 (p=0.009). There was no correlation between 25(OH)D3 and PAW (p=0.063). Conclusion: In our region, the prevalences of osteoporosis and nephrolithiasis were low, indicating moderate clinical presentation and early diagnosis of PHPT. Postoperative hypocalcemia was associated with lower preoperative calcium levels. Low 25(OH)D3 levels were associated with high calcium and PTH but not with PAW. © 2020 by Türkiye Klinikleri.