Effects of Seprafilm(TM) (sodium hyaluranate-based bioresorbable), Sepracoat(TM) (0.4% hyaluronic acid), and Ringer's lactate on the prevention of postsurgical adhesion formation in rat models

Abstract

Forty adult female rats were randomly divided into four groups. Before the standard surgical procedure which consisted of creating a lesion with a lancet over the right uterine horn. Group I received no medication. Ringer's lactate (RL) solution was applied intraperitoneally to Group II at the end of the surgery. Sepracoat solution was applied intraperitoneally to Group III at the onset of the surgery. Group IV randomly received Seprafilm wrapped over the entire right uterine horn. Re-laparotomy was performed 3 weeks later to evaluate the adhesions. The mean adhesion scores were (mean ± SD) 2.90 ± 0.18, 1.00 ± 0.36, 0.50 ± 0.17 and 0.4 ± 0.16 in Groups I, II, III, IV, respectively. The postsurgical adhesions were significantly less in the groups treated with Seprafilm and Sepracoat.