Tuberculosis, renal failure and amyloidosis in the bone marrow (case report)

Abstract

Tuberculosis is a worldwide and chronic disease. Amyloidosis is a systemic disease and it is a well known complication of tuberculosis. Biopsy of the involved organ is required for the diagnosis of amyloidosis and most common used tissues for biopsy are rectum and kidney. In this paper, a patient with renal failure, tuberculosis and amyloidosis, which was shown in the bone marrow is presented. Renal and rectal biopsy could not been performed to the patient because of bleeding tendency and respiratory distress. Bone marrow biopsy showed amyloidosis by Congo Red stain and immunohistochemical study monoclonal antibodies against AA type amyloid fibrils revealed AA type amyloidosis. Bone marrow biopsy should be used initially for the diagnosis of amyloidosis in the patients with renal failure and respiratory distress.