The effects of tenoxicam and Ringer's lactate on post-operative adhesion reformation

Abstract

OBJECTIVE: To determine the effects of tenoxicam, non-steroidal antiinflammatory agent, and Ringer's lactate on adhesion reformation in rat model. STUDY DESIGN: After creating a standard lesion over the right uterine horn of 40 adult female rats, relaparotomy and adhesiolysis were performed intraperitoneally; Group II: tenoxicam, Group III: Ringer's lactate, Group IV: tenoxicam + Ringer's lactate, Group I: Control group. Two weeks later third laparotomy was performed to evaluate the adhesions. RESULTS: The average adhesion scores of group II, III and IV were significantly lower than the score of the control group (p<0.05). The average scores of group II, III and IV didn't show any significant difference (p>0.05), although Group III had a lower score than group II and IV. CONCLUSION: Tenoxicam, when used alone or together with Ringer's lactate solution, significantly decreases adhesion reformation, however, in this study it doesn't reveal any superiority to the classical Ringer's lactate solution.