| dc.contributor.author | Koksal M. | |
| dc.contributor.author | Bilge S.S. | |
| dc.contributor.author | Bozkurt A. | |
| dc.contributor.author | Sahin Z.S. | |
| dc.contributor.author | Isik S. | |
| dc.contributor.author | Erol D.D. | |
| dc.date.accessioned | 2020-06-21T09:24:23Z | |
| dc.date.available | 2020-06-21T09:24:23Z | |
| dc.date.issued | 2008 | |
| dc.identifier.issn | 0004-4172 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12712/3797 | |
| dc.description | PubMed: 19025061 | en_US |
| dc.description.abstract | Several 5-(3,4-dichlorophenyl)-2-(aroylmethyl)thio-1,3,4-oxadiazoles were synthesized and characterized by elemental analyses, IR and nuclear magnetic resonance spectra. All compounds were evaluated for anti-inflammatory activity by determining their ability to provide protection against carregeenan-induced edema in rat paw. In addition, ulcerogenic activity was determined. The anti-inflammatory data scoring showed that compounds 5e, 5f and 5g, at the dose of 100 mg/kg, exhibited anti-inflammatory activity, which for compound 5f was comparable to that of the reference drug indometacin (CAS 53-86-1). © ECV Editio Cantor Verlag. | en_US |
| dc.language.iso | eng | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | 1,3,4-oxadiazoles, antiinflammatory activity, S-alkylation, synthesis, X-ray crystallography | en_US |
| dc.title | Synthesis, characterization and anti-inflammatory activity of new 5- (3,4-dichlorophenyl)-2-(aroylmethyl) thio-1,3,4-oxadiaxoles | en_US |
| dc.type | article | en_US |
| dc.contributor.department | OMÜ | en_US |
| dc.identifier.volume | 58 | en_US |
| dc.identifier.issue | 10 | en_US |
| dc.identifier.startpage | 510 | en_US |
| dc.identifier.endpage | 514 | en_US |
| dc.relation.journal | Arzneimittel-Forschung/Drug Research | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
