Severe peripheral neuropathy secondary to vincristine therapy

Abstract

Patients with hereditary neuropathy at high risk of severe vincristine neurotoxicity are well known. Here, along with a review of the literature, we described two patients with unrecognized hereditary neuropathy who developed foot drop following low dose vincristine therapy. With this report, we wanted to emphasize the importance of detailed neurologic examination and history taking before initiating therapy.