The Efficacy of Alone or Combined Treatment of Aglepristone and Cabergoline on Termination of Mid-term Pregnancy in Cats([1][2])

Abstract

This study determined the efficacy of a combination of aglepristone and cabergoline on termination of mid-term cat pregnancies. Twenty cats with unwanted pregnancies between 30-40 days were included in the study Aglepristone (10 mg/kg, sc) was given to the AGL group (n=6) twice in a 24-h interval. Cabergoline (5 mu g/kg, peros) was administered to the CBG group (n=7) once daily until abortion started or for 8 days. AGL+CBG (n=7) received a combined treatment with both drugs. Abortion occurred in 50% of cats in the AGL group, 71.4% in the CBG group, and 100% in the AGL+CBG. However, the completion of pregnancy termination rate was 85.7% because of fetal retention in one cat from the AGL+CBG group. The interval between treatment-start of abortion (T-SA) was shorter in the AGL+CBG group (3.6 +/- 0.3 days) than in the AGL (6.5 +/- 0.0) and CBG (6.2 +/- 0.2) groups (P<0.01). Similarly, the interval between treatment-end of abortion (T-EA) was shorter in the combined group (4.3 +/- 0.5 days) than the others (7.3 +/- 0.3 and 6.9 +/- 0.9 days, respectively) (P<0.01). Decreasing in progesterone concentration was non-significant in the AGL group from the start of treatment to abortion completion day (dA/d8), but significant in the others (P<0.001). On dA/d8, it was significantly lower in the CBG group (P<0.01) and combined group (P<0.01) than inthe AGL group. Only slight diarrhea was observed in 15.4% of the AGL+CBG group. In conclusion, the AGL+CBG combination increased the rate of abortion induction and significantly shortened T-SA and T-EA with negligible side effects.