Effect of demineralized bone matrix on recovery of median sternotomy in heart surgery

Abstract

Stenosis of secondary sternum, causes to ageing, and this ageing makes diffcult the recovery of bones, and can cause to sliding of sternum from the area that was determined. In our research, we searched that the effect of demineralized bone matrix on recover of sternum that contains noncollagen proteins like osteocalcin, osteonectin and osteopontin that has feature of osteoconductive and osteoinductive. With this purpose, in the clinic of Ondokuz Mayis University department of cardiovascular surgery between November 2009 and October 2010, 24 patients whose ages 65 and 65+ were included into the survey. These patients were randomly divided into two groups, Group I was study group (n=12) and Group II was control group (n=12). To the frst group (study group), at the end of the operation, the putty form of demineralized bone matrix (1 cc) was applied to both sides of medulla of sternum. Any substances weren't applied to the second group (control group). At the end of the operation, sternums of the patients in a standard way was combined with steel wires. All patients had axial reconstruction tomography in preoperative period and 8th week in postoperative period. In these tomographies, density of bones in sternum which was measured as Hounsfeld Unit (HU), was compared with each others. 24 patients, 11 of them were male and 13 of them were female. In this measurements, the density of sternum of patients which was measured in preoperative and postoperative period, were compared with each other; It was diagnosed that for study group p=0.001<0.05 and for control group p=0.000<0.05. While the density of sternum of patients in study group and control group which was measured in 8th week of postoperative period was compared, any statistical differences were not found between both groups. In the end of this research, we think that demineralized bone matrix which is applied to aged patients who have got osteoporotic fragile medulla defection, has not got any accelerate effect on healing of sternum; but in the long term, this substances can prevent breaks seen on bones because of the wires on sternum that cut bones in time. © 2011 OMÜ Tüm haklari saklidir.