The effect of preoperative application of intravenous paracetamol on volatil agent consumption postoperative recovery criterias and postoperative analgesia

Abstract

In this study, we aimed to evaluate the effects of preemptive application of intravenous paracetamol in patients operated under general anesthesia on intraoperative anesthesic consumption, postopoperative recovery criterias and postoperative analgesic requirement. 60 patients between 18-70 years of ages were divided into two groups randomly planned histerectomy. In the preop period, groups were named as Group P were intravenous paracetamol 45 min before operation and intravenous saline applied control group as Group K. Depth of anesthesia was adjusted as to keep bispectral index (BIS) value between 45-55. In preoperative and intraoperative period, heart rate, blood pressure, oxygen saturation, ETCO2, BIS and minimum alveoler consantration (MAC) value, adverse reactions, postoperative aldrete score, amount of volatile agent consumption, extubation time and eye opening time were also recorded. Patient controlled analgesia (PCA) was prepared with meperidine for all of the patients. In postoperative period, PCA use by patients and amount of analgesic consumption, visual analog scale (VAS) values during rest and cough were recorded. Volatile agent consumption was lower in paracetamol group than control group but this was not statistically signifcant. In postoperative period, there was also no difference between analgesic requirement in recovery room, aldrete score and VAS values. PCA usage number and amount of used analgesic were found statistically signifcantly lower in Group P according to Group K (p< 0.05). It was thought that could be alternative in preemptive analgesia intravenous form of paracetamol with lower side effects, wide safety margine, easy usage. © 2011 OMÜ Tüm haklari saklidir.