5-Fluoro-N-(2-methyl-3-oxo-1-thia-4-azaspiro[4.5]dec-4-yl) -3-phenyl-1H-indole-2-carboxamide

Abstract

In the title compound, C24H24FN3O2S, the 1,3-thiazolidine ring adopts an envelope conformation with the S atom as the flap, while the cyclohexane ring is in a chair conformation. In the crystal, molecules are linked by N - H?O and C - H?F hydrogen bonds, forming a three-dimensional network. The unit cell contains six voids of 57 Å3, but the residual electron density (highest peak = 0.23 e Å-3 and deepest hole = -0.19 e Å-3) in the difference Fourier map suggests no solvent molecule occupies this void.