Avascular heterotopic ovarian transplantation into subcutaneous tissue in rats

Abstract

Objective: To assess the recovery, maintenance, and quality of ovarian function by detecting hormonal status and hystopathologic examination of autotransplanted ovary in abdominal wall location in syngeneic winstar rats. Study Design: This experimental study was conducted in the Unit of Experimental Research at the Ondokuz Mayıs University, School of Medicine. Autologous heterotopic transplantation of ovarian tissue was performed without vascular pedicle in rats. Hormone levels were measured on the basal day and at the end of the 12th week. Also, hystopathologic examination of the transplanted ovaries were performed at the end of the experiment. Results: All of the transplanted ovaries were successfully vascularised and there was no necrosis among ovarian species on hystopathological evaluation. It was found out that serum hormone levels of control and transplant group did not show a significant difference in and between the groups. Conclusion: A heterotopic autotransplant of ovary without vascular pedicle in syngeneic Wistar rats was 100% successful without any necrosis in our animals.